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A B S T R A C T S
S17
operative hypofractionated radiotherapy or temozolomide
chemotherapy alone is an option depending on the MGMT
promoter methylation status based on the results of the
NOA-08 and Nordic trials. Treatment options at recurrence
include, among others, the administration of nitrosoureas
such as lomustine as well as the anti-angiogenic agent,
bevacizumab which, however, does not prolong survival
according to several phase III studies in patients with newly
diagnosed or recurrent glioblastoma. Early involvement of
a palliative care team might be warranted in many elderly
patients because of the frequently reduced performance
status and limited life expectancy. Whether elderly patients
may benefit from the currently explored immunotherapeutic
approaches such as vaccination or checkpoint inhibition
needs further investigation within appropriate clinical trials
tailored for this patient population.
Disclosure of interest:
None declared
S53
DO WE NEED GUIDELINES?
Florian Scotté
European Hospital Georges Pompidou, Paris, France
Quality of life (QOL) is hard to assess for patient with or
without cancer. Who Status as well as Karnofsky’s scale
are usually used to grade health status. It is evidence that
those two scales have no impact on accurate assessment.
Edmonton Scale (ESAS) is masterpiece of QOL evaluation for
many teams around the world. Early global care (developed
as early palliative care), proved its interest in better QOL and
survival benefits notably in lung cancer.
First comment is that oncologists and caregivers, in clinical
practice, poorly define QOL status.
As well as fatigue is difficult to define, because of its
multidimensional cause; QOL needs didactic propositions
to be exactly specified. Algorithms clearly conducted and
broadcasted may enhance physician’s involvement.
Second comment; hurdles of QOL evaluation are notably
crucial in elderly population, more frail and likely to
deteriorate during cancer disease.
Many scales exist, with a hazardous use in oncological
physician population.
Pain, fatigue, nutritional status as well as anxiety,
depression and cognitive disorders, should be alleviate but
are bad defined and often misjudged.
Supportive treatments may alleviate suffering and enhance
daily living, as well as anti-cancer treatment adaptation.
Unmet needs must be retrieve and solutions for this must be
developed (Patients Reported Outcome, symptom distress list,
etc.).
In order to offer a multidisciplinary perspective of patient
assessment and practical guidelines, oncologists, geriatric
specialists, pharmacists and nurses will be included in the
committee.
Patient’s view and environment are often better reached
by nurses, it’s because we incorporated nurses involved in the
guideline’s topics, to define elderly and stakeholders unmet
needs.
Elderly patients have often many co morbidities. In that
field, a lot of drugs are used and drug-drug interaction may
impact efficacy as well as safety of anticancer treatments
(and their support drugs). Networks including pharmacists
should be developed in such guidelines propositions.
Disclosure of interest:
None declared
S54
Florian Scotté
European Hospital Georges Pompidou, Paris, France
The speaker abstract has not been received at the time of
publication.
S55
UPDATES IN SURGERY
Ponnandai Somasundar
Boston University, Surgery, Providence, Rhode Island, USA
The introduction is on the physiological decline and
comorbidities resulting in functional decline, improvements
in better assessments to improve the surgical outcomes,
improvements in techniques resulting in better outcomes
such as minimally invasive surgery, better hemostasis, better
postoperative care, and better understanding of the biology of
the disease in the elderly.
Disclosure of interest:
None declared
S56
SPECIAL CONSIDERATIONS WITH REGARD TO COLORECTAL
SURGERY IN THE ELDERLY
Andrea Costanzi
Desio Hospital – ASST Monza, General Surgery, Desio (MB), Italy
Advances in colorectal surgery include multimodal treat-
ments, minimally invasive approach, enhanced recovery,
prehabilation. All items can be applied to the elderly
population which constitutes the majority of the colo-rectal
oncologic patients and a good part of the patients affected
by benign disease. A correct pre-operative evaluation and a
multidisciplinary therapeutic plan offer excellent survival
prognosis and a good quality of life to elderly patients
Disclosure of interest:
None declared