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A B S T R A C T S

S35

optimize patients in advance of surgery. Similarly the higher

number of interventions from social care in the palliative

patient group may reflect their need for increased social

support in the face of their decline in function.

References:

[1]

http://www.ons.gov.uk/peoplepopulationandcommunity/

healthandsocialcare/conditionsanddiseases/bulletins/ca

ncerregistrationstatisticsengland/2014#cancer-diagnoses-

increase-with-age accessed June2016

[2] Wilder H, Heeren P, Puts M et al International Society of

Geriatric Oncology Consensus on Geriatric Assessment in

Older PeopleWith Cancer Journal of Clinical Oncology 2014

Vol 32 Number 24 p2595-2603

[3] Kristjansson S R, Spies C, Veering B.T.H et al Perioperative

care of the elderly oncology patient : A report from the

SIOG task force on the perioperative care of older patients

with cancer. Journal of Geriatric Oncology 2012 volume 3

p147-162.

Disclosure of interest:

None declared

Keywords:

Comprehensive geriatric assessment,

multidisciplinary team, upper GI cancer

O20

A FEASIBILITY TRIAL OF GERIATRIC ASSESSMENT AND

INTEGRATED CARE PLAN FOR OLDER CANCER PATIENTS

M. Puts

1,

*, S. Sattar

1

, K. McWatters

1

, K. Lee

1

, M. Kulik

1

,

M. E. Macdonald

1

, S. Brennenstuhl

1

, R. Jang

2

,

E. Amir

2

, M. Krzyzanowska

2

, A. Joshua

2,3

, J. Monette

4

,

D. Wan-Chow-Wah

5

, S. Alibhai

6,7

1

Lawrence S.Bloomberg Faculty of Nursing, University of Toronto,

2

Medical Oncology, University Health Network, Toronto, Canada,

3

Medical Oncology, Kinghorn Cancer Centre, Sydney, Australia,

4

Division of Geriatric Medicine, Jewish General Hospital,

5

Division

of Geriatric Medicine, McGill University Health Centre, Montreal,

6

Medicine, University Health Network,

7

Medicine, University of

Toronto, Toronto, Canada

Introduction:

A Feasibility Trial of Geriatric Assessment

and Integrated Care Plan for Older Cancer Patients

Objectives:

The majority of persons diagnosed with cancer

are older adults A comprehensive geriatric assessment

(CGA) can identify current health issues and recommend

interventions to decrease adverse outcomes and optimize

the functional status and well-being of older adults. However,

there is limited and conflicting evidence regarding the

effectiveness of CGA in oncology settings. Here, we explore

the impact of a CGA and integrated care plan in optimizing

outcomes in older patients with advanced breast (BC),

gastrointestinal (GI) or genitourinary (GU) cancers using a

randomized controlled trial.

Methods:

A two-group parallel single-blind phase II RCT

enrolled 60 patients aged 70 +, diagnosed with stage 2-4 GI, GU

or BC, referred for chemotherapy or having received <6 weeks

of chemotherapy at the Princess Margaret Cancer Centre,

Toronto, Canada. Patients needed to be fluent in English, had

a life expectancy

6 months, ECOG PS 0-2 and able to provide

informed consent. Randomization to intervention versus

control group was 1:1 and stratified by treatment intent.

The intervention included a full CGA by a multidisciplinary

team. Based on the CGA and discussion with the patient,

tailored evidence-based interventions using a standardized

intervention protocol were implemented. Participants in the

intervention group were seen by the intervention team at

baseline for the CGA and development of the integrated care

plan; and at 3 and 6 months to assess intervention fidelity and

measure outcomes. The co-primary outcomes were: 1) quality

of life (QoL) (EORTC QLQ-C30); 2) modification of the cancer

treatment plan. The secondary outcomes are: 1) functional

status (OARS Instrumental Activities of Daily Living); and 2)

feasibility of the study by tumor site.

Results:

The response rate was 64%. The mean age

of participants in the control group was 75.4 and in the

intervention group 74.7 year. Eighty percent received

chemotherapy with palliative intent in the intervention

group. In both groups about 30% of participants died before

the end of the 6 month follow-up. QoL declined from baseline

to 3 months in both groups; however, the decline was larger

in the control than the intervention group (-6.9 vs. -2.0 points),

especially when considering only those remaining in the

study for at least 6 months (-9.8 vs. -2.8). Modeling the data

using linear regression suggests QoL is 7.1 to 9.3 points higher

in the intervention group at 3 months, adjusting for baseline

differences (p=.34-.38), depending on which subsample is

used.The intervention had no impact on the cancer treatment

plan.The proportion of those with at least one IADL was lower

in the intervention than control group at 3 months, when

adjusting for baseline differences in IADLs (OR

adj

=0.40, p=0.25

95% CI 0.08-1.88).

Conclusion:

This phase 2 pilot study showed that it was

feasible to recruit and retain older adults for a geriatric

assessment and management study. The preliminary efficacy

evaluations showed that the value of GA and management

on change in QoL was greater in the sub-sample of longer-

term survivors/participants than in the whole sample, and

functional decline may be less in the intervention group. A

larger trial is warranted.

Disclosure of interest:

None declared

Keywords:

feasibility study, Geriatric assessment, integrated

care plan, intervention study, randomized controlled trial