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A B S T R A C T S

S115

P132

BARRIERS TO GOOD MEDICATION TAKING BEHAVIOUR IN

METASTATIC PROSTATE CANCER PATIENTS RECEIVING

ORAL ANTI-ANDROGEN THERAPY

S. Ahrari

1,2,

*, K. Farr

1

, L. Buddo

1,3

, A. Thawer

1

, A. Giotis

1

,

M. Puts

4

, C. De Angelis

1,2

1

Pharmacy, Sunnybrook Odette Cancer Centre,

2

Leslie Dan Faculty

of Pharmacy, University of Toronto, Toronto,

3

Pharmacy, University

of Waterloo, Waterloo,

4

Lawrence S Bloomberg Faculty of Nursing,

University of Toronto, Toronto, Canada

Introduction:

Oral anti-cancer medication adherence is of

increasing concern.The metastatic castrate resistant prostate

cancer population (mCRPC) is generally older, with multiple

co-morbidities and medications. These increase barriers to

medication adherence.

Objectives:

To better understand adherence barriers

adherence in mCRPC and identify counseling strategies that

mitigate them.

Methods:

This prospective, exploratory mixed-methods

study included men with mCRPC starting abiraterone or

enzalutamide. After medication counseling, participants

completed validated questionnaires and medication lists,

then were interviewed at 24 hours and 1 month about their

medications.

Questionnaires and demographics was summarized

using descriptive statistics.Semi-structured interviews were

analyzed for underlying themes of effective counseling.

Results:

We evaluated 12 patient responses. Most under-

stood their medications and had good health literacy and

cognitive function. Median age was 77, with three co-

morbidities, seven chronic medications, and strong caregiver

support at home. In addition, most patients had positive

beliefs about medications and good baseline adherence.

Despite positive characteristics, there was an identified gap in

medication counseling efficacy.

First, participants stressed the benefit of having drug

information repeated by multiple providers. In addition,

good medication adherence was associated with tailored

counselling, wherein providers discussed good medication

taking behaviours in the context of individual daily life.

Second, most participants recalled general side effects

and safe handling instructions, but did not recall specific

side effects or management strategies. This is an important

consideration when assessing medication understanding.

Finally, participants had mixed responses regarding drug

information sheets. Usage varied, although participants

appreciated pharmacists highlighting important points as it

provided visual cues that guided drug education sessions.

Conclusion:

In order to maximize the benefit of medication

counseling, health providers should mark information sheets

with important points to tailor education. Tailoring improves

information recall and improves medication adherence.

In addition, breaking counseling sessions into topic-based

chunks improves the flow of counseling and provides time for

patients to absorb information, thus improving confidence.

Regardless of how confident providers are in a patient’s ability

to understand their treatment, there are clear barriers that

need to be overcome in order to ensure safe and efficacious

use of oral anti-cancer agents.

References:

[1] Canadian

Cancer

Society.Toronto.Prostate

cancer

statistics;2014.

[2] D’amato S. Improving Patient Adherence with Oral

Chemotherapy. Oncology Issues. Jul/Aug 2008, 42-5.

[3] Gebbia V et al.Adherence, compliance and persistence

to oral antineoplastic therapy. Expert Opin Drug Saf.

2012;11(S1):S49-59.

[4] Sandelowski M. Sample size in qualitative research. Res

Nurs Health. 1995 April; 18(2):179-183.

[5] Mathes, T et al. Adherence enhancing interventions for

oral anti-cancer agents: A systematic review. Cancer Treat

Rev.2013;40(1):102-8.

[6] Ritchie J, Lewis J. Qualitative Research Practice: A Guide

for Social Science Students and Researchers. London,

UK: SAGE Publications; 2003. Chapter 4, Designing and

Selecting Samples. p.77-108.

[7] Thorne S et al. Interpretive Description: A Noncategorical

Qualitative Alternative for Developing Nursing Knowledge.

Res Nurs Health.1997;20(2):169-77.

Disclosure of interest:

S. Ahrari: None declared, K. Farr:

None declared, L. Buddo: None declared, A. Thawer: None

declared, A. Giotis: None declared, M. Puts: None declared, C.

De Angelis Grant/Research Support from: Astellas Canada

Keywords:

Anti-androgen therapy, medication adherence,

oral anti-cancer medication, patient counseling, prostate,

bladder, kidney, genitourinary cancers

P133

THE DEVELOPMENT OF DISTRESS IN OLDER PATIENTS

WITH CANCER IN THE MID-LONG TERM

S. Dauphin

1,

*, T. De Burghgraeve

1

, F. Buntinx

1,2

,

M. van den Akker

1,2

1

Department of General Practice, KU Leuven, Leuven, Belgium,

2

Department of Family Medicine, Maastricht University, Maastricht,

Netherlands

Introduction:

Older patients with cancer suffer from a

variety of psychosocial problems and distress is one of them.

However, we know little about the evolution of distress over

time (up to three years after diagnosis) and the influence of

baseline characteristics on levels of distress.

Objectives:

To describe the evolution of distress over time

(up to three years after diagnosis) and examine the influence

of baseline characteristics on levels of distress.

Methods:

The KLIMOP study is an ongoing prospective

Flemish - Dutch cohort study. The cohort consists of older

patients with cancer (

70 years) and 2 control groups: middle-

aged patients with cancer (50-69 years) and older people

without cancer (

70 years).Through the use of a questionnaire

we gathered data from the validated Distress Barometer. Data

was collected shortly after diagnosis (baseline, N = 1496)

and three years (preliminary data) after baseline. The data is

analyzed with SPSS 23 using logistic regression.