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S120

A B S T R A C T S

- Identify risk factors for chemotherapy toxicity in older

adults with cancer and manage treatment accordingly

A final round of the Delphi is being conducted to confirm

the consistency of these findings and the final list of geriatric

oncology competencies will be presented.

Conclusion:

Experts in both geriatric oncology and

oncology education agreed upon a set of geriatric oncology

competencies that are appropriate for oncology trainees.

These results will form the groundwork for the development

of a geriatric oncology curriculum for medical oncology

trainees and oncologists.

Disclosure of interest:

None declared

Keywords:

Competencies, Delphi consensus, education,

medical oncology

P140

GERIATRIC RESEARCH POLICY OF THE JAPAN CLINICAL

ONCOLOGY GROUP

T. Mizutani

1,

*, K. Nakamura

1

, A. Ogawa

2

, T. Hmaguchi

1

,

H. Fukuda

1

, F. Nagashima

3

1

National Cancer Center, Tokyo,

2

National Cancer Center Hospital

East, Chiba,

3

Kyorin University School of Medicine, Tokyo, Japan

Introduction:

The goal of the Japan Clinical Oncology

Group (JCOG) is to establish better standard treatments for

various cancer types and has thus conducted several pivotal

randomized controlled trials. Due to the rapidly increasing

ageing population in Japan, clinical research focused on

elderly cancer patients is urgently needed. We have therefore

organized the Geriatric Study Committee (GSC) in JCOG to

develop a geriatric research policy.

Objectives:

The missions of the GSC are as follows (1)

to define the subject selection policy of geriatric research

in JCOG trials; (2) to establish the standard endpoints and

methodological schemes for geriatric research and (3) to

determine the standard tools of geriatric assessment (GA).

Methods:

Therefore, the GCS have held quarterly meetings

since 2014 with members from each disease/modality-

oriented JCOG subgroup. The policy (in Japanese) developed

by the GCS has been extensively reviewed by Executive

Committee members of the JCOG and was activated in May

2016.

Results:

(1) We defined the subject selection policy of

geriatric research by treatment tolerance and chronological

age. We categorized elderly cancer patients into three

conceptual groups: ‘fit elderly cancer patients’ who can

undergo standard treatments as for younger patients; ‘frail

elderly patients’ for whom best supportive care or palliative

care is indicated and ‘vulnerable elderly patients’; those

between ‘fit elderly patients’ and ‘frail elderly patients’. Our

main target for geriatric research is the group of ‘vulnerable

elderly patients’.

(2) The endpoints of geriatric research should include some

GA components, such as physical and cognitive function, in

addition to survival data. From this viewpoint, ‘co-primary

endpoints’ or ‘composite endpoints’ incorporating GA into the

decision rule is often applicable. Furthermore, we classified

typical study designs for the elderly adopted in JCOG into (i) a

randomized controlled trial to establish standard treatments

specifically for elderly cancer patients, (ii) a single arm trial

to extrapolate the results of pivotal trials for the younger

population to elderly cancer patients and (iii) an observational

study for the broader population to explore predictive factors

for survival, functional impairment, or QOL decline.

(3) We determined recommended GA tools from the

viewpoint of simplicity and discriminative power. G8, a

geriatric screening tool, is to be used in all JCOG geriatric

research. Instrumental activities of daily living (IADL),

Charlson comorbidity index (CCI), MINI-COG and the social

situation are also strongly recommended. Other appropriate

tools can be applied depending on the purpose of each

disease/modality-oriented study.

Conclusion:

This JCOG Geriatric Research Policy identified

various issues, which commonly occur in geriatric research.

We expect that this policy would serve as a practical

framework in planning future geriatric research.

Disclosure of interest:

None declared

Keywords:

Geriatric research, policy

P141

COUPLES COPING WITH CANCER IN THE PLATINUM STAGE

OF LIFE: OLDEST-OLD AND THEIR SPOUSAL CAREGIVERS

G. Goldzweig

1

, E. Andritsch

2

, R. Pfeffer

3

, L. Baider

3

,

Y. Rottenberg

4,

*

1

School of Behavioral Sciences, Tel-Aviv-Yaffo Academic College,

Tel-aviv, Israel,

2

Division of Clinical Oncology, The medical

University of Graz, Graz, Austria,

3

Assuta Medical Center, Oncology

Institute, Tel-aviv,

4

Hadassah - Hebrew University Medical Center,

Jerusalem, Israel

Introduction:

The share of the oldest-old (age 86 years old

and above) in the population is estimated to grow rapidly

in the next decades. Yet not much is known about this

population’s adaptation to cancer.

Objectives:

The objective of the current study is to describe

the psychological reaction of the oldest-old and their spousal

caregivers to cancer.

Methods:

Participants were 45 cancer patients, aged 86

years old or above and their spousal caregivers. Participants

completed standardized questionnaires for depression (5-

item GDS), distress (Distress Thermometer), hope (Snyder’s

Hope Scale) and social support (CPASS).

Results:

Patients reported extremely high levels of distress

and low levels of hope. Patients reported high levels of hope

in regard to feeling no pain and to dying without pain but

low levels of hope in regard to staying alive. Spouses reported

significantly lower levels of distress and higher levels of hope.

Patient distress measures were positively correlated with

caregiver levels of hope. There was a significant negative

correlation between caregiver levels of distress and social

support from friends.