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head and neck cancer patients. These measurements may
guide decision-making and customize treatments. More
research is needed to further improve and firmly establish
clinical usability.
Disclosure of interest:
None declared
Keywords:
Adverse health outcomes, functional and
cognitive impairment, geriatric assessment, head and neck
cancer, social environment
P014
DESCRIPTIVE EPIDEMIOLOGICAL STUDY OF GERIATRIC
CANCER SEEN IN TATA MEMORIAL HOSPITAL, MUMBAI
G. Balasubramaniam
1,
*, S. L. Saoba
1
, R. A. Badwe
2
, A. K. Decruz
3
1
Medical records, Biostatistics & Epidemiology, Tata Memorial
Hospital,
2
Director, Tata Memorial Centre,
3
Director, Tata Memorial
Hospital, Mumbai, India
Introduction:
It is well known that age is a known risk
factor for cancer. Annually it is estimated that there are
0.3 million new Geriatric cancer (65 + years) diagnosed in
India, contributing to about 30% of all cancer cases as per
GLOBOCAN 2012. Tata Memorial Hospital (TMH), being a
premier cancer institute in the country, registers substantial
number of geriatric cancer cases. The present study profiles
the geriatric cases seen n TMH over this period.
Objectives:
1. To study the profile of different types of
Geriatric cancers registered in Tata Memorial Hospital (TMH)
during 1999-2008. 2. To know the changing patterns of cancers
in this population
Methods:
Abstraction of information from case records of
the patients registered in TMH and including only those who
were diagnosed as confirmed ‘cancer cases’. As per the WHO
definition, the study included all cases who were aged above
65 years of age at the time of diagnosis and diagnosed at TMH
during 1999-2008. These were classifeed and coded as per the
ICD-O-3. All validitaion and quality checks were done prior
to analysis
Results:
TMH registered 30142 Geriatric cancer (17%) out
of a total of 1,76,230 cancer cases. 19453 were males and
10689 were females and the sex ratio of male to female was
1.8 :1. Major cancer among males, of the lung cancers (12%)
was the leading site of cancer in the geriatric group followed
by Prostate cancer (7.2%), Oesophagus (7.1%), pyriform fossa
(6.8%) and buccal mucosa (4.8), thus contributing to 37% of all
male cancer cases, Major cancer among females were breast
cancer (20.2%), cervix (16.6%), oesophagus (6.4%), buccal
mucosa ( 4.5%), lung cancer (4%) and ovarian cancer ( 3.9%),
thus contributing 55.6% of all female cancers.
Conclusion:
The most common cancers in geriatric group
are similar to the trend seen among adults in terms of the
leading cancers. Though the life-span in Indians are between
60- 75 years, it is quite remarkable that about 15-20% of the
cancers are seen in the geriatric group. This information will
be useful to conduct a detailed study on the life-style factors
in this elderly population
References:
[1] Ferlay J, Soerjomataram I, Ervik M, et al; International
Agency for Research on Cancer. GLOBOCAN 2012 v1.0,
Cancer Incidence and Mortality Worldwide: IARC
CancerBase No. 11.
globocan.iarc.fr.[2] DInshaw KA, Ganesh B, Hospital-based Cancer Registry
Annual Report - 2001, Tata Memorial Hospital, Mumbai,
2005.
[3] DInshaw KA, Ganesh B, Hospital-based Cancer Registry
Annual Report - 2002-05, Tata Memorial Hospital, Mumbai,
2008.
[4] Badwe RA, Mohandas KM, Ganesh B, Hospital-based Cancer
Registry Annual Report - 2005-06, Tata Memorial Hospital,
Mumbai, 2012.
[5] Badwe RA, Decruz Ak Ganesh B, Hospital-based Cancer
Registry Annual Report - 2006-08 Tata Memorial Hospital,
Mumbai, 2014.
Disclosure of interest:
None declared
Keywords:
Epidemiology, geriatric, India, lung, Mumbai
P015
COMBINATION CHEMOTHERAPY WITH DOCETAXEL
AND CARBOPLATIN FOR ELDERLY PATIENTS WITH
ENDOMETRIAL CANCER
H. Yoshida
1,
*, Y. Imai
1
, K. Fujiwara
1
1
Gynecologic Oncology, Saitama Medical University International
Medical Center, Hidaka, Saitama, Japan
Introduction:
The combination of an anthracycline-based
drug, a platinum-containing drug, and a taxane agent are
used in endometrial cancer chemotherapy, and docetaxel and
carboplatin (DC) therapy is one of the important treatment
options. Approximately half of all endometrial cancer cases
are diagnosed in patients older than 65 years. However few
data are available concerning the tolerability and effectiveness
of DC therapy in older patients.
Objectives:
The objective of this study was to compare the
tolerability and effectiveness of first line chemotherapy with
DC therapy between patients older and younger than 65 years
of age with endometrial cancer.
Methods:
Chemotherapy-naive patients with endometrial
cancer were enrolled into this retrospective study between
April 2008 and March 2015. Patients received docetaxel at a
dose of 60 mg/m
2
and carboplatin at area under the curve of
6 mg/ml/min on day 1 of a 3-week cycle. The tolerability and
effectiveness of the regimen were analyzed.
Results:
A total of 41 patients with endometrial cancer
were enrolled into this study. Of these, 26 patients (63%) were
<65 years old and 15 patients (37%) were
65. There were no
significant differences with regard to Eastern Cooperative
Oncology Group performance status score and disease stage
between both groups. Patients older than 65 years were
significantly more likely to have serous or clear cell histology
and high-grade tumors compared with the younger group
(P
= 0.014 and 0.012, respectively). Although the number of
chemotherapy cycles,cycledelays and treatment interruptions