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A B S T R A C T S
S47
of patients younger than 65 years. When patients did receive
chemotherapy, primary and secondary treatment adaptations
were effectuated in 58%: of the patients aged <65 years in 49%
(n=49), for patients aged 65-75 and for both the category of
65-75 years and for older than 75 years in 66% (n=48 and n=
20) treatment adjustments needed to be made. For 44% (n=88)
of all patients treated with chemotherapy unplanned hospital
admissions needed to be made. The guideline recommended
treatment regimen was commenced and completed without
treatment adaptations in only 29% (n=85) of all patients: for
the youngest patients in 40% (n=50), for the middle category in
27% (n=25) and in 13% (n=10) of the elderly. The oldest patient
curatively treated with surgery was 81 years old and the oldest
patient treated with chemotherapy was 86 years old. For the
patients treated with chemoradiotherapy 32% (n=22) started
and finishedwithout treatment adaptations, the oldest patient
treated with sequential chemoradiotherapy was 84 years of
age and treated with concurrent chemoradiotherapy 74 years.
Conclusion:
The decision-making process and course of
treatment for lung cancer vary per age. Especially the patients
between 65-75 years of age are at risk of overestimation and
might be more vulnerable than initially thought. In this age
category chemotherapy was as often started as in patients
aged <65 years, but the guideline recommended treatment
regimen could only be followed as often as in patients aged
75 years and older. Treatment of patients with pulmonary
malignancies is still a challenge, evidence for the elderly is
lacking and more data are therefore urgently needed.
Disclosure of interest:
None declared
Keywords:
Chemotherapy, decision-making, elderly, lung
cancer
P021
POSTOPERATIVE COMPLICATIONS AND MORTALITY IN
INDIVIDUALS AGED 70 AND OLDER UNDERGOING SURGERY
FOR COLORECTAL CANCER
K. Fagard
1,
*, J. Casaer
2
, A. Wolthuis
3
, J. Flamaing
4
, K. Milisen
5
,
J.-P. Lobelle
6
, H. Wildiers
7
, C. Kenis
8
1
Department of Geriatric Medicine, University Hospitals Leuven,
2
Faculty of Medicine, KU Leuven,
3
Department of Abdominal
Surgery, University Hospitals Leuven,
4
Department of Geriatric
Medicine, Department of Clinical and Experimental Medicine,
University Hospitals Leuven, KU Leuven,
5
Department of
Geriatric Medicine, Department of Public Health and Primary
Care, University Hospitals Leuven, Academic Centre for Nursing
and Midwifery, KU Leuven,
6
Consultant in Statistics, University
Hospitals Leuven,
7
Department of General Medical Oncology,
Department of Oncology, University Hospitals Leuven, KU Leuven,
8
Department of General Medical Oncology, Department of Geriatric
Medicine, University Hospitals Leuven, Leuven, Belgium
Introduction:
Reporting of postoperative complications in
older patients undergoing surgery for colorectal cancer (CRC)
often focuses on mortality and surgical complications or
classification into severity scores. Medical complications are
less often reported in detail.
Objectives:
To describe the incidence of in-hospital post-
operative medical and surgical complications and mortality
in individuals aged 70 and older undergoing surgery for CRC.
Methods:
Older patients who had CRC surgery were
identified from a prospectively collected database (2009-
2015). Data were retrieved from the original database; in
addition, in-hospital postoperative complications were
abstracted retrospectively from the medical file. Besides
listing the complications and reporting the major categories,
the encountered postoperative adverse events were classified
into severity grades, using the Clavien-Dindo classification
system.
Results:
One hundred ninety patients (mean = 78 y.) were
studied. 47% of the study population (85/190) experienced one
or more postoperative complications during hospital stay. 77
patients (40.5%) had medical complications and 34 patients
(17.9%) had surgical complications. 30-day postoperative
mortality was 1.6%. 72 patients (38%) experienced severe
complications (Clavien-Dindo
grade II). Infectious compli-
cations were the most common medical complications and
occurred in 26.8% of the patients. Other medical compli-
cations in descending order were: neurological (12.6%),
non-infectious abdominal (5.3%), cardiovascular (5.8%), non-
infectious urinary (3.7%), non-infectious respiratory (2.6%)
and thromboembolic (1.6%) complications.The most common
surgical complications during the postoperative hospital stay
were surgical site infections (SSI): 12%. The majority of these
SSIs were organ/space SSI (62.2%). Anastomotic leak occurred
in 3.7% of the study population. Surgical site bleeding occurred
in 3.7% of patients. Re-intervention rate was 9%.
Conclusion:
Our findings show that complications after
surgery for colorectal cancer in patients aged 70 and over
are frequent. This study provides information to clinicians
regarding the in-hospital postoperative course in older
patients with CRC.
Disclosure of interest:
None declared
Keywords:
Colorectal cancer, elderly, mortality, postoperative
complications, surgery
P022
EFFICACY AND SAFETY OF ANTIANGIOGENIC THERAPIES
IN ELDERLY PATIENTS WITH METASTATIC RENAL CELL
CARCINOMA: A RETROSPECTIVE MULTICENTER STUDY
L. Pierard
1,
*, F. Schaff-Wendling
1
, A. Thiéry
2
, C. Korenbaum
1
,
J. Gantzer
1
, D. Heitz
1
, B. Duclos
1
, C. Borel
3
, J.-E. Kurtz
1
,
P. Barthélémy
1
1
Medical Oncology Unit, University Hospital Strasbourg,
2
Epidemiology and Biostatistics Department,
3
Medical Oncology
Unit, Centre Paul Strauss, Strasbourg, France
Introduction:
Antiangiogenic agents (AA) (sorafenib,
sunitinib, pazopanib) have demonstrated clinical activity in
first-line treatment of metastatic renal cell carcinoma (mRCC).
However, elderly patients have been underrepresented in the
large randomized pivotal trials. Furthermore, side effects are
common and might become an issue in elderly patients (pts).