119 / 154
A B S T R A C T S
S89
significant positive correlation between Rockwood FI and the
gold standard (CGA) (n= 147; R=+0.74, p<0.0001).
CGA unmasked several clinical problems in 108 out of 147
examined oncogeriatric patients, such as nutritional deficit
(39%) and mood disorders(46%), followed by a significant
percentage of post surgical delirium (8%). To date, the overall
mortality was of11% (17/147 patients). The 30-day mortality
after surgery was of 4% (2/50 pts).
Conclusion:
The study results indicate a significant
correlation between CGA and Rockwood IF and address a
different predictive accuracy of IF in stratifying the pre frail
patients’ category. The larger enrolment and follow up of
the study will allow to identifying the best predicting tool in
oncogeriatrics, improving as well the clinical assessment and
management of the pre frail oncogeriatric patients.
Disclosure of interest:
None declared
Keywords:
Accurate tool, clinical outcomes, frailty, geriatric
assessment, rockwood frailty index
P088
THE ONCOLOGICAL MULTIDIMENSIONAL PROGNOSTIC
INDEX (ONCO-MPI) HELPS PREDICTING BENEFITS OF
TREATMENT FOR PATIENTS WITH ADVANCED COLORECTAL
CANCER: A PROSPECTIVE SINGLE CENTER STUDY
A. Brunello
1,
*, S. Lonardi
1
, F. Bergamo
1
, R. Intini
1
, L. V. Rumanò
1
,
S. Ahcene-Djaballah
1
, P. Fiduccia
2
, A. Lettiero
1
, G. Tierno
1
,
A. Pilotto
3
, V. Zagonel
1
1
Medical Oncology 1 Unit,
2
Clinical Trials and Biostatistics Unit,
Istituto Oncologico Veneto, Padova,
3
Geriatric Care, Orthogeriatrics
and Rehabilitation, Frailty Area, Galliera Hospital, Genova, Italy
Introduction:
Comprehensive geriatric assessment
(CGA) helps identifying pts who could benefit more from
oncological treatment. Items of domains explored in the CGA
are heterogeneous, depending on type of assessment, which
make it difficult to integrate results in the decision-making
process.
Our group recently developed a CGA-based Onco-
MPI, a numeric score which predicts accurately the probability
of 1 year mortality in older cancer pts [1].
Objectives:
The aim of this study is to describe the role of
Onco-MPI in pts selection for oncological treatment.
Methods:
Pts aged 70 years or older with a diagnosis
of colorectal cancer (CRC) were assessed with a full CGA.
Data of the single CGA items were used to calculate Onco-
MPI scores, which were registered but not made available to
treating oncologists. Vital status was recorded as of December
31
st
2015. Overall survival was estimated with Kaplan-Meier
method.
Results:
Five hundred and nine pts aged
70 were
evaluated, median age 77 years (range 70 - 93), 304 (59.7%)
male, 202 (39.7%) with advanced stage disease. Globally, 120
pts (25.3%) were low-risk, 179 pts (37.7%) intermediate-risk
and 176 (37%) high-risk, according to Onco-MPI. Survival
analysis was conducted for 475 pts (34 excluded because of
missing data). Pts’ characteristics are described in Table 1.
Onco-MPI confirmed to be a highly accurate predictive tool
for one-year mortality in older CRC pts (log-rank p<0,001). For
pts with stage IV CRC (N=202, 39.7%), there was a significant
impact of treatment in pts with intermediate risk onco-MPI
(N=56 pts, p 0,01), with pts undergoing oncological treatment
showing better survival. In pts with high-risk Onco-MPI
(N=137) no significant impact of oncological treatment on
survival was seen.
Table 1 (abstract P088) – Characteristics of patients
No. of patients (n (%))
509 (100)
BMI (median (range))
24 (14 - 54)
ADL (mean ± SD)
5,65 ± 0,84
IADL (mean ± SD)
6,78 ± 1,67
PS (mean ± SD)
0,6 ± 0,73
No. of comorbidities (mean ± SD)
1,49 ± 1,43
MMSE (
=24)
394 (77,4)
No. of drugs (mean ± SD)
3,52 ± 2,58
Caregiver (Yes)
495 (97,2)
Conclusion:
Older pts with advanced CRC and
intermediate-risk Onco-MPI may benefit from oncological
treatment, whereas pts with high risk Onco-MPI did not show
a benefit from chemotherapy. Onco-MPI may serve as a useful
tool to integrate decision-making for older pts with advanced
colorectal cancer.
Reference:
[1] Brunello A, Fontana A, Zafferri V, et al. Development of an
oncological-multidimensional prognostic index (Onco-
MPI) for mortality prediction in older cancer patients. J
Cancer Res Clin Oncol. 2016 May;142(5):1069-77.
Disclosure of interest:
None declared
Keywords:
Chemotherapy, colorectal cancer, geriatric
assessment, onco-MPI, treatment
P091
FUNCTIONAL DECLINE IN OLDER PATIENTS WITH
CANCER RECEIVING CHEMOTHERAPY: A MULTICENTER
PROSPECTIVE STUDY
C. Kenis
1,
*, L. Decoster
2
, J. Bastin
3
, H. Bode
3
, K. Van Puyvelde
4
,
J. De Grève
2
, G. Conings
2
, K. Fagard
5
, J. Flamaing
6
, K. Milisen
7
,
J.-P. Lobelle
8
, H. Wildiers
9
1
General Medical Oncology and Geriatric Medicine, University
Hospitals Leuven, Leuven,
2
Medical Oncology, Oncologisch centrum,
Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels,
3
General Medical Oncology, University Hospitals Leuven, Leuven,
4
Frailty in Aging (FRIA) Research Group & Gerontology Department,
Vrije Universiteit Brussel, Brussels,
5
Geriatric Medicine, University
Hospitals Leuven,
6
Geriatric Medicine & Clinical an Experimental
Medicine,
7
Geriatric Medicine & Public Health and Primary Care,
Academic Centre for Nursing and Midwifery, University Hospitals
Leuven & KU Leuven, Leuven,
8
Consultant in Statistics, Beernem,
9
General Medical Oncology & Oncology, University Hospitals
Leuven & KU Leuven, Leuven, Belgium
Introduction:
Maintenance of functional status (FS) is
a key issue for older persons, certainly for those diagnosed
with cancer. Repeated assessment of FS over time gives
treating physicians the opportunity to identify functional