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A B S T R A C T S
Conclusion:
The needs assessment uncovered rich
information about the challenges and unique needs of the
GU cancer care team and potential value of a GO clinic to
optimally care for older adults with cancer.
Disclosure of interest:
None declared
Keywords:
Genitourinary cancer disease site, geriatric
oncology needs assessment, knowledge and attitudes,
oncologist, oncology nurses
P083
PRE-OPERATIVE ASSESSMENT AND POST-OPERATIVE
OUTCOMES OF ELDERLY WOMEN WITH GYNECOLOGIC
CANCERS, PRIMARY ANALYSIS OF NRG CC-002
A. Ahmed
1,
*, W. Deng
2
, W. Tew
3
, D. Bender
4
, R. Littell
5
,
A. DeNittis
6
, M. Edelson
7
, M. Morgan
8
, J. Carlson
9
, L. Small
10
,
A. Fleury
11
, S. Modesitt
12
, A. Olawaiye
13
, A. Evans
14
, G. Fleming
15
and NRG Oncology
1
OBGYN, Gynecologic Oncology, Rush University Medical Center,
Chicago,
2
GOG, Buffalo,
3
Memorial Sloan Kettering, new york,
4
University of Iowa, Iowa City,
5
Kaiser Permanente, San Francisco,
6
Mainline, Wynnewood,
7
Abington Jefferson Health, Abington,
8
University of Pennsylvania, Philidelphia,
9
Cancer Center Research
for the Ozarks, Springfield,
10
Maine Medical Partners, Scarborough,
11
Women’s Caner Center of Nevada, Las Vegas,
12
University of
Virginia, Charlottesville,
13
University of Pittsburgh, Pittsburgh,
14
Marshfield Clinic, Marshfield,
15
University of Chicago, Chicago, USA
Introduction:
CC-002isaprospectivecooperativegroupstudy
conducted by the National Clinical Trials Network (NCTN)
group NRG Oncology to evaluate whether a pre-operative
GA-GYN score derived from a predictive model utilizing
components of an abbreviated geriatric assessment (GA)
will be associated with major post-operative complications
in elderly women with suspected ovarian, fallopian tube,
primary peritoneal or advanced stage papillary serous uterine
(GYN) carcinoma undergoing primary open cytoreductive
surgery.
Objectives:
The primary objective in this study is to
evaluate whether a pre-operative GA-GYN score derived from
a predictive model utilizing components of an abbreviated
geriatric assessment (GA) will be associated with major post-
operative complications in elderly women with suspected
ovarian, fallopian tube, primary peritoneal or advanced stage
papillary serous uterine (GYN) carcinoma undergoing primary
open cytoreductive surgery.
Methods:
Patients age 70 years or older with suspected
ovarian, fallopian tube, primary peritoneal or advanced stage
papillary serous uterine carcinoma undergoing evaluation for
surgery were eligible to enroll. Prior to cytoreductive surgery,
patients completed an abbreviated geriatric assessment
consisting of reliable assessment measures that are primarily
self-administered. The assessment includes measures of
functional status, comorbidity, psychological state, social
support,social activity,andnutrition.This geriatric assessment
tool has been validated and used in other cooperative group
studies (Hurria et al, JCO, 2011). Patients were followed for six
weeks post-operatively or until start of chemotherapy. Post-
operative complications were defined as the occurrence of an
event listed in The American College of Surgeons’ National
Surgical Quality Improvement Program. Events were recorded
as a yes/no occurrence, or meeting severity criteria of grade 3
or higher using CTCAE version 4.0.
Results:
190 patients were enrolled from February 2015
to November 2015. Of 190 patients, 116 patients planned to
have primary open cytoreductive surgery, 38 patients planned
to have neoadjuvant chemotherapy followed by interval
cytoreductive surgery, 36 patients did not have surgery. Of the
116 patients, 105 patients had primary open cytoreductive
surgery and will be included in the primary analysis. 81% of
the 105 patients were ages 70-79 years of age; the majority had
a performance status of 0 or 1 and was of white race. In the
105 patients, 5 patients had pending post-operative events,
30 protocol-defined post-operative events were reported
including two death events during the 6-week post-operative
follow up period, and 11% were re-admitted to the hospital
within 30 days of surgery. The data for the primary objective,
the association between the score from the predictive model
and post-operative complications, is maturing.
Conclusion:
We hypothesize that a patient with higher
pre-operative GA-GYN score is more likely to have major post-
operative complications. Currently the data for the primary
objective is maturing and will be ready for presentation in the
near future.
Disclosure of interest:
None declared
Keywords:
Cytoreductive surgery, geriatric assessment,
gynecologic cancer
P084
PREDICTION OF FUNCTIONAL DECLINE AND 1 YEAR
SURVIVAL IN ELDERLY CANCER PATIENTS USING
COMPREHENSIVE GERIATRIC ASSESSMENT
A. L. Kanaji
1,
*, W. Jacob Filho
1
, T. Karnakis
1
, L. A. Gil Jr
1
,
T. C. A. Rotta
1
1
Geriatrics, ICESP, São Paulo, Brazil
Introduction:
Older patients with cancer comprise a
heterogeneous group of patients. Chronological age should
not be the cornerstone to cancer treatment decision since
co morbidities; functionality, cognition and physiological
reserve vary among this population. There are few studies
that evaluate the comprehensive geriatric assessment (CGA)
efficacy in predicting functional decline and survival in the
elderly patients with cancer.
Objectives:
To determine the 1 year functional decline
and survival in elderly cancer patients followed in a geriatric
outpatient clinic.
Methods:
We analyzed baseline record data from patients
aged
60 years with active solid tumors enrolled in a geriatric
outpatient clinic from July 2013 until June 2014. Primary
outcome was functional decline in 1 year, defined as a loss of at
least 1 of de basic activities of daily living. Secondary outcome
was survival in 1 year. Phone calls were made to verify the