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S102

A B S T R A C T S

Methods:

A prospective observational, multicentre study

including patients

70 years with a newly diagnosed,

histologically confirmed cancer or first relapse after previous

curativetreatment.Atinclusion,themGAwasperformedpartly

by trained nurses and partly using self-report questionnaires.

The assessment included eight domains; nutrition (Patient-

Generated Subjective Global Assessment), comorbidity

(Physical Health Section, Older Americans’ Resources and

Services comorbidity scale), regular medications, falls the

past six months, activities of daily living, physical (Timed

Up and Go), cognitive (Mini Mental State Examination) and

emotional function (Geriatric Depression Scale-15). For each

domain, a cut-off value for impaired function was defined.

Patients were categorized as frail if at least one domain was

registered as impaired. All other patients were categorized as

non-frail. Blinded for the mGA categorization and without any

specific instructions, the oncologists were asked to categorize

patients as fit, intermediate or frail. The intermediate (n=89)

and frail (n=15) category was merged into one category

named “suspected frail”. The agreement between mGA frail

and “suspected frail” was assessed by Kappa statistics. The

association of frailty and ”suspected frailty” with OS was

investigated by bi- and multivariate Cox regression analyses

adjusting for age, sex, cancer diagnosis, ECOG Performance

Status, stage and treatment.

Results:

This abstract presents baseline data. Between

January 2013 and April 2015, 307 patients were enrolled at 8

hospitals. Of these, 288 patients (94%) completed all baseline

questionnaires and thus the mGA, 286 patients had frailty

rated by the oncologists. Median age was 77 (70-95) years,

160 patients (56%) had distant metastasis, most common

cancer diagnoses were colorectal (n=83, 29%), lung (n=59,

21%) and prostate (n=56, 19%). In all, 140/288 (49%) patients

were categorized as mGA-frail, 104/286 (36%) patients were

“suspected frail”. The overall agreement between the two

frailty categorizations was 65%, Kappa measurement value

was 0.30 (95% CI 0.19; 0.41), representing fair agreement. The

median follow up time for survival was 16.9 months; 45%

of patients were alive at date of censoring. In bivariate Cox

regression analyses being frail according to both the mGA (HR

1.86 (95% CI 1.36; 2.56)) and the oncologists’ clinical judgment

(HR 1.94 (95% CI 1.41; 2.66)) was significantly associated with

reduced OS (p<.01). In the multivariate models, only mGA

frailty was significantly associated with reduced OS with a HR

of 1.61 (95% CI 1.14; 2.27) (p<.01).

Conclusion:

A systematic mGA identified more patients

as frail than the oncologists’ subjective clinical judgment.

Frailty categorized by the modified geriatric assessment was

an independent negative prognostic factor and provides

important, additional prognostic information for oncologists.

Disclosure of interest:

None declared

Keywords:

Frailty, geriatric assessment

P112

A PROSPECTIVE NON-INTERVENTIONAL STUDY ON

THE USE OF BEVACIZUMAB AND CONVENTIONAL

CHEMOTHERAPY FOR FIRST-LINE TREATMENT OF

METASTATIC COLORECTAL (MCRC) PATIENTS: SCREENING

AND GERIATRIC ASSESSMENT (GA)

L. Decoster

1,

*, C. Kenis

2

, G. Houbiers

3

, B. Naessens

4

,

M. De Man

5

, G. Lambrecht

6

, V. Moons

7

, E. Monsaert

8

,

P. Vergauwe

9

, H. Prenen

2

, E. Van Cutsem

2

, E. Beutels

10

,

D. Frijns

11

, H. Wildiers

2

1

UZ Brussels, Brussels,

2

UZ Leuven, Leuven,

3

Gastroenterology

and Digestive Oncology, CHC Clinique St Joseph, Liege,

4

AZ

Nikolaas, St.Niklaas,

5

OLV Aalst, Gent,

6

AZ Damiaan, Oostende,

7

Imeldaziekenhuis, Bonheide,

8

AZ Maria Middelares, Gent,

9

AZ

Groeninge, Kortrijk,

10

Innosens,

11

Roche NV/SA, Brussels, Belgium

Introduction:

In Belgium, the average age at diagnosis of

CRC is 70.1 years for men and 71.6 years for women. Few

elderly with cancer are included in clinical trials and aging

is a heterogeneous process. Therefore, choosing the most

appropriate therapy and weighing the risks and benefits of

chemotherapy in older cancer patients is challenging. Geriatric

screening and GA allow evaluation of individual global health

status and treatment optimisation. This observational study

aims to complement the knowledge on chemotherapy and

bevacizumab usage in elderly with mCRC in current practice

in Belgium and evaluates the impact of baseline geriatric

screening and GA on treatment duration (TD), progression

free survival (PFS) and severe toxicity.

Objectives:

Primary objective was TD of first-line bevacizu-

mab-containing chemotherapy. Secondary objectives were

TD of conventional chemotherapy, safety of bevacizumab in

elderly and correlation of baseline geriatric screening and GA.

Methods:

252 patients

70 years with mCRC receiving

chemotherapy with/without bevacizumab were included in

the study. Geriatric screening with G8 and Flemish Triage

Risk Screening Tool (fTRST), Eastern Cooperative Oncology

Group (ECOG), as well as GA including activities of daily

living (ADL), instrumental activities of daily living (IADL),

Mini-Mental State Examination (MMSE), Geriatric Depression

Scale (GDS-15), Mini Nutritional Assessment (MNA), Charlson

Comorbidity Index (CCI), and Mobility-Tiredness Test (Mob-T)

was performed in all patients at baseline. Logrank tests (for

TD and PFS), Wilcoxon or Student t-tests (for severe toxicity)

and multivariate analyses were used for correlations with

the different screening and GA components. A subgroup

analysis excluding patients with ECOG

2 at baseline was

also performed.

Results:

In the total safety population, median TD (95%

CI) was 5.5 (5.1-6.2) months. The only baseline parameters

significantly associated with TD in univariate analysis

were ECOG

1, which was only 14.6% of patients, and MNA

(p=0.0006 and p=0.0162, respectively), while G8 showed a

trend (p=0.0607). Significant correlations were observed

for PFS versus ECOG (p<0.0001), MNA (p=0.0001) and G8

(p=0.0208) and for severe toxicity versus ECOG (p<0.0001) and

G8 (p=0.005). Both TD and PFS were significantly associated

with G8 (p=0.0093 and p=0.0002, respectively) when lowering

the G8 cut-off to 12 (i.e. median value). fTRST did not show