Journal of Geriatric Oncology - Volume 7/6 - Supplement 1 - November 2016

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A B S T R A C T S S69
As lung cancer generally has a poor prognosis, patients need
to be informed about these aspects of treatments as well.
Future research should focus on optimal patient selection as
well as a better recognition of the last phase of life. This could
aid in optimizing the quality of dying as well as the quality
of life.
Disclosure of interest: None declared
Keywords: Elderly, end of life care, lung cancer, quality of life
P057
MANAGEMENT OF ELDERLY PATIENTS SUFFERING FROM
CANCER: ASSESSMENT OF PERCEIVED BURDEN AND
QUALITY OF LIFE OF PRINCIPAL CARER
V. Quipourt1,2, L. Bengrine Lefevre2,3,*, S. Dabakuyo4,
S. Marilier1,2, P. Manckoundia1, P. Arveux4, V. Germain5
1Geriatrician, CHU DIJON, 2UCOG Bourgogne, 3Medical oncology,
4statistician, Centre Georges François Leclerc, 5General practitioner,
liberal practitioner, DIJON, France
Introduction: The cancer incidence increases with age.
Anticancer treatment as chemotherapy is more discussed and
must be adapted to comorbidities and geriatric assessment.
Cancer is considered now as a chronic disease and lead to
increased family’s burden. In France, one of the objectives of
2014-2019 Cancer Plan is to consider needs of family or near
carers.
Objectives: The main objective was to evaluate the
perceived burden and the quality of life (QoL) at 3 and 6
months of the principal carer (PC) of cancer patients aged 70
and over and assessed a geriatric oncology consultation.
Methods: The Geriatric Oncology Coordination Unit
in Burgundy performed a multicenter prospective study
conducted over a 9 months period with a follow-up at 3
and 6 months. Each patient referred to a geriatric oncology
consultation for geriatric assessment designed a PC, who was
included in the study after signing consent.
Two questionnaires were proposed at inclusion, 3 and 6
months: the medical Outcomes study 12-item Short Form
health Survey (SF 12) and the Zarit Burden Interview (ZBI).The
PCs were divided into 4 classes according to the ZBI score: low
charge (score 20), light charge (between 21 and 40), moderate
charge (between 41 and 60) and severe charge (60).
Quantitative variables were described using means and
standard deviation. Qualitative variables were analyzed by
variance.The major determinants of QoL were identified using
mixed models of analysis of variance (ANOVA). Statistical
analyses were performed by SAS 9.4 software.
Results: Ninety six PC were included. The mean age was
64±15, 55.2% were female and 48.9% were a child. Sixty four
and six percents of PC were present during the geriatric
consultation. The Zarit Scale showed that 45.8% of PCs felt a
low charge, 29.2% a mild charge and 8.3% a moderate to severe
charge. The ZBI scores were 20.1±14.5, 19.6±14.8 and 19.9±15.5
points at inclusion, 3 and 6 months. The QoL was significantly
decreased by at least 5 points for “emotional damage”
and “physical pain” dimensions. Regarding the emotional
dimension in multivariate analysis: age of the PCs (<70 years
p=0.005), a low perceived burden (p<0.0001) and the PCs of
patients with an ADL score5 (p=0.01) remained significantly
and independently associated with QoL of the PCs. For
physical pain dimension, in multivariate analysis, only the
low perceived burden (p<0.001) and no hormonotherapy
treatment (p<0.0001) were significantly associated with PCs
QoL.
The mean age of patients was 81±5.2 and 76.5% were
female. Fifty nine and two percents had formalized help and
55% lived with their spouse/partner or child. The mean ADL
and IADL score were 5.4±0.9 and 5.9±2.4. The MMSE score
was normal in 62.6% of patients, but showed light alteration
in 19.8% of cases, moderate alteration in 13.2% and severe
alteration in 4.4%. During the follow-up, 2 patients were
institutionalized and 17 died from cancer.
Conclusion: This prospective study was an original work
of the perceived burden of PCs in France. Cancer treatment
seemed not to affect the PC’s QoL. The main determinants
were inherent to PC’s factors (age and perceived burden) and
the patient’s functional independence. Others studies are
needed to propose appropriate support to preserve PC’s QoL.
References:
[1] Zarit S. Relatives of the impaired elderly: correlates of
feelings of burden. Gerontologist 1980;20:649-655.
[2] Mazzotti E et al. Predictors of mood disorders in cancer
patients’ caregivers. Support Care Cancer 2013;21:643-647.
Disclosure of interest: None declared
Keywords: Burden, elderly cancer patients, principal carer,
quality of life
P058
NEUTROPHIL ENGRAFTMENT AND GRAFT-VERSUS-
HOST DISEASE IN ELDERLY PATIENTS UNDERGOING
HEMATOPOIETIC STEM CELL TRANSPLANTATION:
IMPORTANCE OF BODY COMPOSITION ASSESSMENT AND
GERIATRIC
L. Koch1,*, R. J. Garcia Filho1, N. Hamerschlak1,
A. D. A. e Castro1, C. C. da Silva1, A. Tachibana1, C. Prado2,
A. Z. Pereira1
1Department of Medical Oncology, Hospital Israelita Albert Einstein,
Sao Paulo, Brazil, 2Department of Nutrition, Food and Exercise
Sciences, University of Alberta, Edmonton, Canada
Introduction: It is well established that the loss of muscle
mass is the biggest change that occurs with aging and may
lead to decline of muscle strength and functionality. In 1989,
Irwin Rosenberg proposed the term “sarcopenia” to describe
this decline in muscle mass is related to aging. Patients with
hematologic malignancies are usually well nourished before
undergoing the hematopoietic stem cell transplantation
(HSCT). However, changes in body composition after HSCT
have been the subject of studies. After HSCT, complications
such as infections and graft-versus-host disease (GVHD) might
affect the weight and body composition. Immunosuppressive
therapy and corticosteroids also alter skeletal muscle